Alzheimer's Disease as Progressive Neural Decoherence An Integrative Sympathetic Harmonic Resonance Framework (SHRF)

This work presents an integrative, service-oriented reinterpretation of Alzheimer’s disease using the Sympathetic Harmonic Resonance Framework (SHRF). Rather than treating amyloid-beta and tau pathology as isolated primary causes, Alzheimer’s disease is reframed as a progressive failure of multiscale neural coherence driven by sustained boundary-condition stress, including metabolic instability, vascular insufficiency, immune dysregulation, sensory loss, and sleep disruption. The framework preserves and integrates established molecular, genetic, immunological, vascular, and network-level findings while explaining early functional decline, symptom fluctuation, network-based propagation, partial reversibility in…