Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications
Chinese Academy of Medical Sciences & Peking Union Medical College · Peking Union Medical College Hospital
Abstract
Cancer cells orchestrate a highly dynamic and interconnected network spanning metabolic, epigenetic, and immune mechanisms to drive adaptive plasticity and continuous development. This review synthesizes emerging insights into the coevolutionary strategies employed by malignant and stromal cells-particularly tumor cells and immune populations-across the continuum of tumorigenesis, metastasis, and treatment resistance. During tumor initiation, cancer cells rewire metabolism and generate oncometabolites that reshape the chromatin architecture to support immune evasion. Concurrently, metabolic competition in the tumor microenvironment (TME) induces epigenetic exhaustion of cytotoxic T cells, whereas…
Citation impact
- FWCI
- 75.00
- Percentile
- 100%
- References
- 489
Authors
10- XWXing WangCorresponding
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
- XLXiyuan Luo
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
- RXRuiling Xiao
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
- XLXiaohong Liu
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
- FZFeihan Zhou
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
Topics & keywords
- Epigenetics
- Reprogramming
- Immune system
- Chromatin
- Tumor microenvironment
- Stromal cell
- Cancer cell
- Acquired immune system