Emotional and cognitive effects of menopause and hormone replacement therapy
University of Cambridge · Cambridge School · +2 more institutions
Abstract
Menopause is a natural physiological process, but its effects on the brain remain poorly understood. In England, approximately 15% of women use hormone-replacement therapy (HRT) to manage menopausal symptoms. However, the psychological benefits of HRT are not well established. This study aims to investigate the impact of menopause and HRT on mental health, cognitive function, and brain structure.
We analyzed data from nearly 125,000 participants in the UK Biobank to assess associations between menopause, HRT use, and outcomes related to mental health, cognition, and brain morphology. Specifically, we focused on gray matter volumes in the medial temporal lobe (MTL) and anterior cingulate cortex (ACC).
Citation impact
- FWCI
- 84.11
- Percentile
- 100%
- References
- 46
Authors
6- KZKatharina Zühlsdorff
University of Cambridge
- CLChristelle Langley
University of Cambridge, Cambridge School, Bridge University
- RBRichard Bethlehem
University of Cambridge
- VWVarun Warrier
University of Cambridge
- RRRafael Romero Garcia
University of Cambridge, Cambridge School, Bridge University, Instituto de Biomedicina de Sevilla
Topics & keywords
- Menopause
- Hormone replacement therapy (female-to-male)
- Cognition
- Mental health
- Estrogen replacement therapy
- Adverse effect