Bioinformatics-Driven, Plant-Based Antibiotic Research Against Quorum Sensing and Biofilm Formation in Pseudomonas aeruginosa and Escherichia coli Multiresistant Microbes
University of Modena and Reggio Emilia · Sapienza University of Rome · +2 more institutions
Abstract
Quorum-sensing (QS) systems play a crucial role in regulating virulence, biofilm formation, and antibiotic resistance in clinically relevant microbes. This review explores the potential of QS systems as targets for developing novel plant-based therapeutic strategies using bioinformatics, aimed at combating highly pathogenic bacteria: uropathogenic Escherichia coli (UPEC) and Pseudomonas aeruginosa. We examine the key components and molecular pathways of QS systems in these microbes, including autoinducer synthases, receptors, and regulatory proteins. In UPEC, we discuss the LuxS-dependent autoinducer (AI)-2 system, while for P. aeruginosa, we analyze the more complex interconnected Las, Rhl, and PQS circuits.…
Citation impact
- FWCI
- 36.03
- Percentile
- 99%
- References
- 259
Authors
7Topics & keywords
- Quorum sensing
- Biofilm
- Pseudomonas aeruginosa
- Virulence
- Autoinducer
- Antibiotic resistance
- In silico
- Antibiotics