Wearable Nanosensor for Noninvasive Multimodal Monitoring of Theophylline Pharmacokinetics and Hemodynamics
Northeast Normal University · Interface (United States) · +3 more institutions
Abstract
Monitoring the dynamic interactions between therapeutic drugs and physiological responses is essential for advancing precision medicine. The inter- and intrasubject variability in drug pharmacokinetics and physiological responses underscores the need for simultaneous and continuous monitoring of both parameters to address the limitations of current approaches that are invasive and unable to capture dynamic drug-body interactions. Here, we report a fully integrated epidermal nanosensor (termed PharmHemoSens) that enables real-time, noninvasive, and multimodal sweat monitoring of theophylline (THP), a widely prescribed medication for asthma, alongside key hemodynamic signals, including heart rate and blood…
Citation impact
- FWCI
- 39.68
- Percentile
- 100%
- References
- 58
Authors
6- JWJiayi Wang
Northeast Normal University, Interface (United States), Hebei University of Science and Technology, Integrated Optoelectronics (Norway)
- JBJing Bai
Northeast Normal University, Integrated Optoelectronics (Norway)
- CMChong-Bo Ma
Northeast Normal University, Integrated Optoelectronics (Norway)
- MGMeihua Gu
Northeast Normal University, Integrated Optoelectronics (Norway)
- MSMimi SunCorresponding
Jilin Normal University, Northeast Normal University, Integrated Optoelectronics (Norway)
Topics & keywords
- Pharmacokinetics
- Theophylline
- Hemodynamics
- Drug
- Continuous monitoring
- Bioavailability
- Good health and well-being