Win Ratio Method for Hierarchical Composite Outcomes in Randomized Clinical Trials

Cunningham, J. Thomas; Fuest, Stephen; Burke, Harry

doi:10.1001/jama.2025.25686

articleJAMAJan 28, 2026Closed access

Win Ratio Method for Hierarchical Composite Outcomes in Randomized Clinical Trials

JTJ. Thomas Cunningham SFStephen Fuest HBHarry Burke

The University of Texas at San Antonio Health Science Center · The University of Texas at San Antonio · +2 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

This Guide to Statistics and Methods provides an overview of the win ratio method for analyzing composite end points in randomized clinical trials, including its benefits and limitations.

Citation impact

total citations

FWCI: 118.70
Percentile: 100%
References: 10

Too recent for citation history.

Authors

JT
J. Thomas CunninghamCorresponding
The University of Texas at San Antonio Health Science Center, The University of Texas at San Antonio
SF
Stephen Fuest
University of Colorado Anschutz Medical Campus
HB
Harry Burke
George Washington University

Topics & keywords

Topics

Statistical Methods in Clinical Trials48%
Advanced Causal Inference Techniques12%
Statistical Methods and Bayesian Inference8%

Keywords

Randomized controlled trial
Clinical trial
MEDLINE
Composite number
N of 1 trial

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