Zinc‐Complex Orchestrating Pyroptosis for Hypoxia‐Tolerant Photoimmunotherapy
Sichuan University · Sichuan Agricultural University · +3 more institutions
Abstract
ABSTRACT Photon‐driven pyroptosis represents an advanced and promising modality in anti‐tumor immunotherapy, offering new avenue in combating cancer recurrence and metastasis. Essential metal‐complex shows great potential in photoimmunotherapy, which however hardly generates reactive oxygen species (ROS) to active photoimmunotherapy under light irradiation due to low spin–orbit coupling (SOC) resulting in intersystem crossing (ISC) being blocked. To address this challenge, we innovatively proposed the concept of essential‐metal ion as an electron‐withdrawing group to modulate the donor‐acceptor (D‐A) system, thereby significantly improving ROS generation efficiency. As a proof of concept, we designed and…
Citation impact
- FWCI
- 74.38
- Percentile
- 100%
- References
- 50
Authors
10Topics & keywords
- Immune system
- Immunosuppression
- Pyroptosis
- Immunogenic cell death
- Programmed cell death
- Reactive oxygen species
- Cancer
- Cancer cell