BCMA-CD19 armored compound CAR T cells in systemic lupus erythematosus: extended follow-up of a phase 1 clinical trial

CD19 CAR T-cells have shown promise in treating systemic lupus erythematosus (SLE), however, relapses demonstrate persistently elevated autoantibodies characteristic of CD19-negative long-lived plasma cells (LLPCs). Alternatively, ICG318, a dual-targeting BCMA-CD19 armored CAR T-cell therapy, targets both B cells and plasma cells/LLPCs driving SLE which may improve outcomes. Herein, we present 12 patients with refractory SLE, including 10 with lupus nephritis (LN), who received ICG318 CAR T-cells resulting in 10 of 12 achieving stringent complete remission (sCR) defined by medication-free DORIS CR and complete renal response (CRR). Eleven of 12 achieved drug-free, serological CR. Nine patients underwent repeat…

• NS
  Natural Science Foundation of Guangdong Province

  Award: 2021A1515011320