Emerging landscape of KRAS inhibitors in cancer treatment

Alterations in KRAS , NRAS , and HRAS occur in roughly 20% of patients with cancer, making RAS one of the most intensively studied oncogenic targets. The discovery of mutant-selective KRAS G12C inhibitors has provided a proof-of-concept for RAS-directed therapies, heralding a new era in the treatment of RAS-driven cancers. Yet, the efficacy of first-generation KRAS G12C inhibitors is limited by the rapid emergence of resistance. Novel classes of (K)RAS inhibitors with distinct mechanisms of action and broader target coverage hold promise to overcome resistance and extend the benefits of RAS-targeted therapies to a wider patient population. In this review, we summarize clinical evidence for KRAS G12C inhibitors…

• CC
  Conquer Cancer Foundation
• AS
  American Society of Clinical Oncology
• AS
  Austrian Science Fund

  Award: J 4911-B
• SU
  Stand Up To Cancer