BODIPY-Doped Nanocarrier Engineering (BONE) Improves Bone Marrow mRNA Delivery by NIR-II Bioimaging Guided Screening
National University of Singapore · Fudan University · +6 more institutions
Abstract
Efficient delivery of mRNA to the bone marrow is crucial for maintaining immune homeostasis and understanding the pathogenesis of numerous disorders. However, achieving effective delivery remains challenging due to the low blood perfusion of bone tissue and the restrictive blood–bone marrow barrier. Conventional strategies for developing and screening bone-targeting carriers mainly rely on in vitro bone-binding assays and lack robust in situ evaluation tools. Here, we report a BODIPY-doped nanocarrier engineering (BONE) strategy that leverages NIR-II bioimaging for guided development and screening of mRNA delivery systems targeting the bone marrow. A library of NIR-II-emissive BODIPY dyes with intrinsic bone…
Citation impact
- FWCI
- 62.61
- Percentile
- 100%
- References
- 43
Authors
11- BLBenhao Li
National University of Singapore, Fudan University, Smart Material (Germany), Advanced Energy Materials (United States)
- JWJianbo WangCorresponding
Jiaxing University
- PYPeng Ye
National University of Singapore
- CLChaoying Liu
Fudan University, Jiaxing University, Smart Material (Germany), Advanced Energy Materials (United States)
- YMYang Ming
National University of Singapore
Topics & keywords
- Bone marrow
- Nanocarriers
- Transfection
- Immune system
- Flow cytometry
- Gene delivery
- Drug delivery