The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events
Centre National de la Recherche Scientifique · Université Paris Cité · +10 more institutions
Abstract
Reward processes have traditionally been ascribed to dopamine (DA)-associated circuits. While external stimuli, such as food and drugs of abuse, are activators of DA-neuron activity, growing evidence indicates that interoceptive signals also play a critical role. Among these, the gut-brain vagal axis has emerged as a key regulator, although its precise contribution to mesolimbic DA signaling and behavior remains unclear. Here, we combine complementary ex vivo and in vivo approaches across multiple scales to show that gut-brain vagal tone is essential for gating mesolimbic DA system activity and functions, modulating DA-dependent molecular and cellular processes, and scaling both food- and drug-induced…
Citation impact
- FWCI
- 102.00
- Percentile
- 100%
- References
- 79
Authors
16- OOOriane Onimus
Centre National de la Recherche Scientifique, Université Paris Cité, Unit of Functional and Adaptive Biology
- FAFaustine ArrivetCorresponding
Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Institut de Biologie Paris-Seine
- TLTinaïg Le BorgneCorresponding
Centre National de la Recherche Scientifique, Université Paris Sciences et Lettres, Laboratoire Plasticité du Cerveau, ESPCI Paris
- SPSylvie PérezCorresponding
Centre National de la Recherche Scientifique, Inserm, Collège de France, Université Paris Sciences et Lettres, Centre Interdisciplinaire de Recherche en Biologie
- JCJulien Castel
Centre National de la Recherche Scientifique, Université Paris Cité, Unit of Functional and Adaptive Biology
Topics & keywords
- Reward system
- Dopamine
- Mesolimbic pathway
- Gating
- Nucleus accumbens
- Nerve net
- Optogenetics
- Feeding behavior
- Zero hunger