Chromene-based enaminones: Versatile precursors for the synthesis of new 1-phenyl-1 H -pyrazole-3-carboxylate hybrids with potential MRSA inhibitory potency

The goal of the current work is to explore the antibacterial potency, especially MRSA inhibitory activity, of new ethyl 4-(2-oxo-2H-chromene-3-carbonyl)-1-aryl-1H-pyrazole-3-carboxylates 1a-1l. The desired products are obtained, in 77–95% yields, by reacting the appropriate chromene-based enaminones with the various hydrazonyl chlorides utilizing a suitable [3 + 2] cycloaddition protocol. The aforementioned protocol was conducted using an equimolar amount of triethylamine in refluxing dioxane for 6–8 h. Some new chromene-pyrazoles showed promising bacterial inhibitory efficacy, especially against Staphylococcus aureus and Enterococcus faecalis. Ethyl 1-(4-nitrophenyl)-1H-pyrazole-3-carboxylate hybrids 1d and…