Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing
Wenzhou Medical University · First Affiliated Hospital of Wenzhou Medical University · +4 more institutions
Abstract
Impaired diabetic wound healing is driven by immune dysregulation and microenvironmental disruptions induced by hyperglycemia, leading to excessive inflammation and defective macrophage polarization. Although macrophage extracellular traps (METs) play critical roles in chronic inflammatory diseases, their involvement in shaping the diabetic wound immune microenvironment and impeding macrophage polarization remains insufficiently understood. Here, we present zinc-containing bioactive glass (ZnBG), in which zinc incorporation confers immunomodulatory properties. In a type 2 diabetic full-thickness skin excision model, ZnBG significantly mitigates MET-associated oxidative stress and inflammation. Mechanistic…
Citation impact
- FWCI
- 46.61
- Percentile
- 99%
- References
- 63
Authors
12- RSRuiyang SunCorresponding
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Ningbo No.6 Hospital
- XWXuebo Wei
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University
- ZSZhuoyang Song
Wenzhou Medical University
- JLJunjun Luo
Wenzhou Medical University
- JYJingyi Ye
Wenzhou Medical University
Topics & keywords
- Macrophage polarization
- Macrophage
- Inflammation
- Immune system
- Wound healing
- Oxidative stress
- Reactive oxygen species
- M2 Macrophage