Sepsis and the immunometabolic inflammatory response

Sepsis is a life-threatening syndrome characterised by dysregulated immunity, inflammation and metabolic disruption. Despite improved care, it remains a major cause of morbidity and mortality, highlighting the need for improved mechanistic insight. Immunometabolism has emerged as a framework for understanding sepsis pathophysiology. Conventional prognostic tools reflect downstream organ injury but not the metabolic states of immune cells. Emerging technologies now enable high-resolution profiling of immunometabolic changes and integrating these approaches may yield metabolic biomarkers capable of tracking immune function and refining diagnostics. This review summarises current knowledge of leukocyte metabolic…

• QM
  Queen Mary University of London
• BC
  Barts Charity

  Award: G-002143
• BA
  Biotechnology and Biological Sciences Research Council

  Award: BBX009610