From organoid culture to manufacturing: technologies for reproducible and scalable organoid production

Kim, Dohui; Youn, Jaeseung; Kim, Juhyeok; Lee, Jeongmin; Yoon, Jangwon; Kim, Dong Sung

doi:10.1038/s44385-025-00054-6

articlenpj Biomedical Innovations.Feb 2, 2026DIAMOND OA

From organoid culture to manufacturing: technologies for reproducible and scalable organoid production

DKDohui Kim JYJaeseung Youn JKJuhyeok Kim JLJeongmin Lee JYJangwon Yoon

Pohang University of Science and Technology

PubMed

Indexed incrossrefdoajpubmed

Abstract

In this review, we systematically categorize diverse organoid engineering strategies-including cellular programming, material engineering, and platform- or system-level innovations-according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.

Citation impact

11

total citations

FWCI: 90.91
Percentile: 100%
References: 193

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Authors

6

Topics & keywords

Topics

Keywords

Organoid
Scalability
Cognitive reframing
Production (economics)

UN Sustainable Development Goals

Industry, innovation and infrastructure

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