articleMedCommJan 31, 2026GOLD OA

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

Binzhou University · Chinese Academy of Medical Sciences & Peking Union Medical College · +3 more institutions

PubMed
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Abstract

Biomedical research models are undergoing continuous evolution, while conventional models (two-dimensional/ three-dimensional cultures and animal studies) face limitations in physiological relevance and ethical constraints. Against this backdrop, the integration of organ-on-a-chip (OoC) technology with multi-omics methodologies is driving a profound paradigm shift in the field. OoC platforms utilize microfluidic technology to construct biomimetic three-dimensional microenvironments capable of highly simulating human physiological and pathological states, while multi-omics technologies (e.g., proteomics, transcriptomics, and metabolomics) provide systematic molecular profiling capabilities. The integration of…

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