Electrochemical Gating of d-Band Engineering in Hierarchically Bridged Dual-Site Nanozymes for Synergistic Cascade Catalysis and Wearable Biosensing
National University of Singapore · Qingdao University of Technology · +4 more institutions
Abstract
Cascade nanozymes for biosensing are fundamentally hampered by diffusion limitations and passive catalytic sites. Herein, we report a strategy of electrochemical gating of d-band engineering within a hierarchically bridged dual-site nanozyme (CuNCs@FeMOP) to achieve dynamic control over cascading catalysis. This architecture spatially confines the ascorbic acid oxidase-mimicking copper nanocluster (CuNC) core and the peroxidase-mimicking iron-based microporous organic polymer (FeMOP) shell, eliminating intermediate diffusion losses. More critically, synergistic electronic coupling via a histidine bridge provides static preoptimization of the Cu and Fe sites’ d-band structure, enhancing their intrinsic…
Citation impact
- FWCI
- 32.36
- Percentile
- 100%
- References
- 30
Authors
8- HCHuining ChaiCorresponding
National University of Singapore, Qingdao University of Technology
- XSXi Sun
Qingdao University, Intelligent Health (United Kingdom), Qingdao University of Technology
- XTXiao Tan
Qingdao University of Technology
- ZYZhishuang Yuan
Qingdao University of Technology
- JGJing Guan
Qingdao University of Technology
Topics & keywords
- Ascorbic acid
- Catalysis
- Biosensor
- Gating
- Cascade
- Coupling (piping)
- Microelectrode