articleCellFeb 4, 2026HYBRID OA

Molecular architecture of human dermal sleeping nociceptors

JKJannis KörnerDHDerek HowardHJHans Jürgen SolinskiMMMarisol Mancilla MorenoNHNatja Haag

Universitätsklinikum Aachen · RWTH Aachen University · +9 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains elusive, preventing targeted therapy. Using a Patch-seq approach, we combined single-cell transcriptomics, following electrophysiological characterization, with single-nucleus and spatial transcriptomics from pigs and integrated our findings with cross-species and human transcriptomic data. We functionally identified CMis in pig sensory neurons with patch clamp, using adapted protocols from human microneurography. We identified oncostatin M receptor (OSMR) and somatostatin (SST) as…

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9
total citations
FWCI
147.47
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100%
References
77
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Authors

29

Topics & keywords

Topics
Keywords
  • Nociceptor
  • Oncostatin M
  • Transcriptome
  • Human skin
  • Neuropathic pain
  • Sensory system
  • Electrophysiology
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