Interface-engineered plasmonic covalent organic framework nanofilms on TiO  2  nanotubes for universal mass spectrometry imaging

Xu, Yizhu; Wu, Xinzhou; Li, Weifeng; Hu, Jiadu; Chen, Xiran; Chen, Yingying; Yin, Zhibin; Hang, Wei

doi:10.1126/sciadv.adx8264

articleScience AdvancesFeb 4, 2026GOLD OA

Interface-engineered plasmonic covalent organic framework nanofilms on TiO 2 nanotubes for universal mass spectrometry imaging

YXYizhu Xu XWXinzhou Wu WLWeifeng Li JHJiadu Hu XCXiran Chen

South China Agricultural University · Shenzhen Second People's Hospital · +2 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Covalent organic frameworks (COFs) hold promise for surface-assisted laser desorption/ionization mass spectrometry imaging (MSI), yet their integration with plasmonic nanostructured platforms remains unexplored. Here, we report a liquid-liquid interfacial self-assembly strategy to construct plasmonic gold nanoparticle–decorated COF nanofilms on titanium dioxide nanotubes. This hierarchical design synergizes plasmonic enhancement, efficient charge transfer, and enhanced ionization efficiency, achieving sensitivity improvement over conventional matrices. The plasmonic platform affords universal compatibility with currently available biosample preparation protocols including imprinting, stamping, and…

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Topics

Keywords

Plasmon
Titanium dioxide
Mass spectrometry
Bridging (networking)
Covalent bond
Non-covalent interactions
Nanoparticle
Covalent organic framework

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