A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway

Prolonged periodontal inflammation and progressive alveolar bone loss are typical manifestations of periodontitis. Antioxidative therapies targeting the central role of reactive oxygen species (ROS) have been explored, but lack of subcellular specificity limits efficacy. Mitochondria function as an upstream redox hub that drives oxidative stress, inflammatory responses, and alveolar bone resorption, making mitochondrial redox modulation a promising yet underexplored strategy for periodontitis therapy. Herein, we developed a mitochondria-targeted, redox-responsive nanocomposite (TC/pSeSe) that enables programmable redox modulation of the pathological periodontal microenvironment. The antioxidative core consists…

• NN
  National Natural Science Foundation of China

  Awards: 82404097, 82401063, 82270953, 82130027
• NU
  National University's Basic Research Foundation of China
• NK
  National Key Research and Development Program of China

  Award: 2023YFC2413600
• FR
  Fundamental Research Funds for the Central Universities

  Award: YG2024QNB16