Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis

Precise control of chemo- and regioselectivity in intermolecular difunctionalization of alkenes remains a long-standing challenge in organic synthesis. Here, we report a heterogeneous cobalt single-atom-site catalyst that enables selective 1,2-sulfonamidoazidation of styrenes. The system features good functional group tolerance and excellent recyclability. By leveraging the characteristics of single-atom-site catalysis, this work provides a valuable platform for achieving highly selective, efficient, and sustainable styrene functionalization.

• NN
  National Natural Science Foundation of China

  Awards: 22371083, 22001086
• NK
  National Key Research and Development Program of China

  Award: 2023YFC2308000
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 22500021, 2024BRB003