The influence of neuro-tumor interactions on tumorigenesis and therapeutic response
Longgang Central Hospital · Central South University · +9 more institutions
Abstract
The intricate crosstalk between the nervous system and tumors has emerged as a pivotal determinant of tumorigenesis, progression, and therapeutic response. This review synthesizes current insights into neuro-tumor interactions, highlighting how neuronal networks within the tumor microenvironment (TME) modulate cancer cell proliferation, invasion, and angiogenesis by releasing neurotransmitters, growth factors, etc. The neuro-immune axis, a critical interface linking neural signaling to immune regulation, is explored in depth, elucidating how neuronal-derived molecules influence the phenotype and function of immune cells (e.g., T cells, macrophages, natural killer (NK) cells) to affect anti-tumor immunity. In…
Citation impact
- FWCI
- 83.23
- Percentile
- 100%
- References
- 271
Authors
11Topics & keywords
- Crosstalk
- Immune system
- Tumor microenvironment
- Signal transduction
- Carcinogenesis
- Cancer
- Nervous system
- Angiogenesis