articleAlimentary Pharmacology & TherapeuticsFeb 8, 2026Closed access

Liver Steatosis‐Related Polygenic Risk Score Predicts Hepatocellular Carcinoma Risk After Hepatitis C Virus Eradication

YLYu‐Sheng LinYLYing‐Cheng LinYCYun‐Yu ChenYAYi‐Ming Arthur ChenICI‐Chieh Chen

International Baccalaureate · National Chung Hsing University · +7 more institutions

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Abstract

ABSTRACT Background and Aims Genetic predisposition to hepatic steatosis may increase hepatocellular carcinoma (HCC) risk after hepatitis C virus (HCV) eradication in cirrhotic patients; however, its impact on broader patient populations remains unexplored. We aimed to evaluate the association of steatosis‐polygenic risk score (PRS) with HCC following direct‐acting antiviral (DAA) therapy. Methods This retrospective cohort study utilised data from the Taiwan Precision Medicine Initiative, including adults treated with DAAs for HCV. Patients with treatment failure, hepatitis B virus co‐infection, significant alcohol use, or HCC diagnosis prior to sustained virological response at 24 weeks were excluded. All…

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Topics & keywords

Topics
Keywords
  • Hepatocellular carcinoma
  • Hepatitis C virus
  • Polygenic risk score
  • Hepatitis C
  • Hepacivirus
  • Risk assessment
  • Risk factor
UN Sustainable Development Goals
  • Good health and well-being
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