articlePLoS ONEFeb 10, 2026GOLD OA

Artificial intelligence agents in healthcare research: A scoping review

Yale University · Ohio University · +10 more institutions

PubMed
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Abstract

Introduction

Artificial Intelligence (AI) agents are rapidly transforming healthcare delivery, enabling real-time decision support and sophisticated patient interaction at scale. However, the scientific landscape of this rapidly growing, multidisciplinary field remains fragmented, with technical innovation outpacing translational research and the establishment of ethical governance frameworks. To address this gap, we conducted a comprehensive scoping review analysis of AI agent research in healthcare.

Methods

We followed scoping review methodology (PRISMA-ScR guidelines). Searches across PubMed, Web of Science, arXiv, and medRxiv were conducted from January 2015 to December 7, 2025.

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