How do nanoparticle properties shape pharmacokinetics and pharmacodynamics? A mechanistic review
Instituto Politécnico Nacional · Zapata (United States) · +2 more institutions
Abstract
Many therapeutics fail due to suboptimal pharmacokinetics/pharmacodynamics (PK/PD), and the development of nanomedicine remains partly empirical. We present a protocol-guided, mechanistic review that links nanoparticle (NP) physicochemical traits (such as size, surface charge/hydrophobicity, elasticity, and composition) to protein-corona remodeling, immune recognition, biodistribution, and clearance across the ADME, and examines how these shifts translate into pharmacodynamics and therapeutic index. We systematically searched PubMed, Web of Science, Scopus, and ClinicalTrials.gov (primarily 2000–2025) using predefined Boolean strings. We included in vivo animal or human studies directly comparing the same drug…
Citation impact
- FWCI
- 37.33
- Percentile
- 100%
- References
- 90
Authors
6- EPEsperanza Peralta-CuevasCorresponding
Instituto Politécnico Nacional
- NYNahomi Y. Degollado-Hernández
Zapata (United States), Universidad Tecnológica Emiliano Zapata del Estado de Morelos, Instituto Politécnico Nacional
- ICIliana C. Martínez-Ortíz
Instituto Politécnico Nacional
- AJAshley J. Gutierrez-Onofre
Instituto Politécnico Nacional
- IGIgor Garcia-Atutxa
Universidad Católica de Murcia
Topics & keywords
- Nanomedicine
- Pharmacokinetics
- Pharmacodynamics
- Transcytosis
- Drug
- Tofacitinib
- Nanoparticle
- Drug discovery