Octopamine and tyramine dynamics predict learning rate phenotypes during associative conditioning in honey bees

Biogenic amines are fundamental for physiological homeostasis and behavioral control in both vertebrates and invertebrates. Monoamine neurotransmitters released in target brain regions conjointly regulate adaptive learning and plasticity. However, our understanding of these multianalyte mechanisms remains nascent, in part due to limitations in measurement technology. Here, during associative conditioning in honey bees, we concurrently tracked subsecond fluctuations in octopamine, tyramine, dopamine, and serotonin in the antennal lobe, where plasticity influences odorant representations. By repeatedly pairing an odorant with subsequent sucrose delivery, we observed individual differences in the conditioned…

• NS
  National Science Foundation

  Awards: CRCNS 2113179, 1559632
• UD
  U.S. Department of Energy

  Award: SC0021922
• BA
  Bill and Melinda Gates Foundation
• AV
  Alexander von Humboldt-Stiftung
• WT
  Wellcome Trust

  Award: 091188/Z/10/Z
• L
  Lundbeckfonden

  Award: R368-2021-325
• M
  Max-Planck-Gesellschaft

  Award: 203147/Z/16/Z
• HL
  H. Lundbeck A/S
• NI
  National Institutes of Health

  Award: NIDCD R01 DC020892-01