Highly Expressive Bienzyme and Photothermal Effect Co-Enabled by the Co–O–Mn Bridge for Potentiating 1550 nm Light-Triggered Photodynamic Therapy
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +5 more institutions
Abstract
Development of single-atom nanocatalysts with photoresponsive and enzyme-like properties has opened innovative avenues for improving the tumor photodynamic therapy (PDT) effect. However, their further application was restricted by the insufficient adsorption/desorption for multireaction intermediates and poor light tissue penetration. Herein, we constructed mesoporous silica-supported, O-bridged asymmetric cobalt–manganese (Co–O–Mn) dual-atom nanozyme, coated on the surface of 1550 nm-excited upconversion (UC) nanoparticles and modified with polyethylene glycol (denoted as P/U@CoMnDA), for the PDT, thermal-enhanced enzyme dynamic therapy, and magnetic resonance imaging. Interestingly, the incorporation of…
Citation impact
- FWCI
- 31.29
- Percentile
- 99%
- References
- 84
Authors
10- CLChang Li
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Rare Earth Resources Utilization, Northeast Forestry University
- SLShuang Liu
Northeast Forestry University
- JXJiating XuCorresponding
Heilongjiang Academy of Forestry, Northeast Forestry University
- JQJiawei Qu
Northeast Forestry University
- ZTZhengyang Tang
Northeast Forestry University
Topics & keywords
- Photothermal therapy
- Photodynamic therapy
- Nanomaterial-based catalyst
- Photothermal effect
- Substrate (aquarium)
- Photon upconversion
- Nanoparticle
- Polyethylene glycol