Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
Ghent University · VIB-UGent Center for Inflammation Research · +7 more institutions
Abstract
The choroid plexus (ChP), located in the brain ventricles, is largely composed of ChP epithelial cells that produce the cerebrospinal fluid (CSF) and form the blood–CSF barrier. At the ChP–brain attachment sites, we have discovered unique fibroblasts referred to as ChP base barrier cells (BBCs). We show that ChP BBCs originate from meningeal mesenchymal precursors, arrive early during development, remain throughout life and are conserved across species. ChP BBCs are transcriptionally similar to meningeal arachnoid barrier cells and are interconnected by both adherens and tight junctions. Notably, we provide evidence that the BBCs function as a barrier, controlling communication between the periphery and…
Citation impact
- FWCI
- 79.45
- Percentile
- 100%
- References
- 69
Authors
22- DVDaan VerhaegeCorresponding
Ghent University, VIB-UGent Center for Inflammation Research
- CDClint De Nolf
Ghent University Hospital, Ghent University, VIB-UGent Center for Inflammation Research
- LVLore Van Acker
Ghent University, VIB-UGent Center for Inflammation Research
- WCWouter Claeys
Ghent University Hospital, Ghent University, VIB-UGent Center for Inflammation Research
- JCJonas Castelein
Ghent University, VIB-UGent Center for Inflammation Research
Topics & keywords
- Choroid plexus
- Parenchyma
- Adherens junction
- Compartmentalization (fire protection)
- Cerebrospinal fluid
- Blood–brain barrier
- Central nervous system