articleOrganic LettersFeb 16, 2026Closed access

Photocatalyzed Site-Selective Formal β-C(sp 3 )–H Sulfonylation of Ketones with Sulfinates

Hangzhou Normal University · Kementerian Pendidikan Malaysia · +1 more institution

PubMed
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Abstract

)-H sulfonylation of ketones. This method operates under mild conditions and exhibits broad functional group compatibility. Its utility is demonstrated through scalable synthesis and the late-stage functionalization of complex molecules. Mechanistic investigations suggest a reaction pathway involving a photoinduced hydrogen atom transfer (HAT) step, followed by copper-mediated reductive elimination. This protocol provides a direct route to valuable β-sulfonyl ketones from readily available starting materials and inexpensive reagents.

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Authors

6

Topics & keywords

Keywords
  • Photocatalysis
  • Surface modification
  • Formal synthesis
  • Functional group
  • Catalysis
  • Reaction conditions
  • Photoredox catalysis
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