articleAnalytical MethodsJan 1, 2026Closed access

Novel green-emissive carbon dots as a dual-purpose fluorometric tool for sensitive vismodegib detection and pharmacokinetic analysis

AMAli M. AlaseemRORazan OrfaliGAGlowi AlasiriRARamadan AliABAl‐Montaser Bellah H. Ali

Imam Mohammad ibn Saud Islamic University · University of Tabuk · +1 more institution

PubMed
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Abstract

Accurate determination of vismodegib (VISMO), a Hedgehog pathway inhibitor approved for the management of basal cell carcinoma and other malignancies, is essential for pharmacokinetic assessment, dose optimization, and therapeutic drug monitoring. In this work, a novel green-emitting "turn-off" fluorometric probe based on nitrogen-doped carbon dots (G-N@CDs) was designed and optimized for the ultrasensitive and selective determination of VISMO in biological matrices. The fluorescence quenching behavior of the probe was predominantly governed by a synergistic combination of the inner filter effect and static quenching mechanisms, indicative of strong ground-state complexation between VISMO and surface…

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Topics & keywords

Topics
Keywords
  • Vismodegib
  • Detection limit
  • Pharmacokinetics
  • Fluorescence
  • Quenching (fluorescence)
  • Selectivity
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