articleBritish Journal of Clinical PharmacologyFeb 17, 2026GREEN OA

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

SKSrinivas KamathNSNicole S. L. ChanPJP Joyce

The University of Adelaide

PubMed
Indexed incrossrefpubmed

Abstract

Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research. Mounting evidence suggests that the gut microbiota modulates GLP-1 secretion via microbial metabolites, including short-chain fatty acids and bile acid derivatives, while GLP-1 agonists reciprocally reshape microbial composition, influencing metabolic outcomes beyond their classical incretin functions. This bidirectional interplay has profound implications for precision medicine, as gut microbial signatures have been associated with variability in therapeutic…

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8
total citations
FWCI
72.07
Percentile
100%
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80
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3

Topics & keywords

Topics
Keywords
  • Microbiome
  • Gut flora
  • Gut microbiome
  • Incretin
  • Dysbiosis
  • Type 2 diabetes
  • Metagenomics
  • Microbial metabolism
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