articleScience AdvancesFeb 18, 2026GOLD OA

Multiple southward migrations of Neolithic Chinese farmers into Southeast Asia revealed from large-scale Y-chromosome sequences

MWMengge WangYLYunhui LiuLLLintao LuoZWZhiyong WangYFYuhang Feng

Sichuan University · West China Hospital of Sichuan University · +6 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The scale and timing of genetic contributions from ancient millet- and rice-farming populations in China to Southeast Asian populations remain incompletely understood, particularly concerning Y-chromosome diversity. Here, a comprehensive dataset of Chinese Y-chromosome variations, including 1507 high-coverage sequences from ethnolinguistically diverse groups, was analyzed alongside 780 ancient genomes from eastern Eurasia and 1748 low-coverage sequences from Southeast Asia. We reconstructed a high-resolution, time-calibrated Y-chromosome phylogeny, revealing multiple male-biased expansions associated with Neolithic cultural innovations in South China. These expansions markedly shaped the paternal ancestry of…

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Topics & keywords

Keywords
  • Southeast asia
  • Haplogroup
  • Phylogeography
  • Mainland
  • China
  • Middle East
  • Human migration
  • Ancient DNA
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