Mitochondrial oxidative stress to PANoptosis: Current evidence and therapeutic implications for neurological diseases

• Mitochondrial dysfunction and oxidative stress are key drivers of neurodegeneration. • PANoptosis exacerbates neuronal dysfunction and cell death in neurological diseases. • Mitochondrial dysfunctions and oxidative stress are key inducers of PANoptosis activation. • Mitochondria-targeted antioxidants hold significant potential for inhibiting PANoptosis. • PANoptosis inhibition demonstrates multiple neuroprotective effects in neurological disease. Mitochondrial oxidative stress is a key driver of neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, and spinal cord injury, promoting neuronal dysfunction and degeneration through multiple pathways. PANoptosis, a recently characterized…

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  National Natural Science Foundation of China