articleMechanobiologyFeb 18, 2026HYBRID OA

Nanotopography-guided cellular mechanobiology: Mechanotransduction pathways and applications in tissue engineering

SSSeong-Jin ShinJLJung-Hwan LeeSOSeunghan Oh

Dankook University · Wonkwang University

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Abstract

Nanotopography has emerged as a powerful tool for regulating cellular behavior through mechanotransduction. This review explores how engineered nanoscale features, including grooves, ridges, and pillars, modulate integrin clustering, cytoskeletal organization, and nuclear signaling via YAP/TAZ and PIEZO1, ultimately influencing cell fate, epigenetic remodeling, and tissue regeneration. We discuss the hierarchical pathways linking extracellular topographies to chromatin regulation, emphasizing cell-type–specific responses in mesenchymal stem cells, fibroblasts, and myoblasts. Advances in nanofabrication, including electron-beam lithography, nanoimprinting, electrospinning, and self-assembly, have enabled…

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Topics & keywords

Topics
Keywords
  • Extracellular matrix
  • Mechanotransduction
  • Chromatin
  • Tissue engineering
  • Mesenchymal stem cell
  • Mechanobiology
  • Nanotopography
  • Integrin
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