Alginate-Based Hydrogels: Recent Progress in Preparation, Property Tuning, and Multifunctional Applications

Alginate-based hydrogels, derived from brown seaweed, represent biocompatible and biodegradable materials whose properties are systematically controlled through molecular structure (M/G composition), crosslinking strategy, and compositional modification. This review synthesizes recent advances in alginate hydrogel design, encompassing fundamental structural properties, three primary crosslinking approaches—ionic coordination with divalent cations (Ca2+, Ba2+, Sr2+), covalent chemical linkages, and hybrid multi-crosslinking systems—and strategic modification strategies including chemical derivatization, polymer blending, and nanoparticle incorporation. These modifications address inherent limitations of native…

• NN
  National Natural Science Foundation of China

  Award: No. 82204482