Phytochemicals and REDOX Modulation: Molecular Mechanisms, Clinical Relevance, and Therapeutic Perspectives

Oxidative stress and redox (REDOX) imbalance play a key role in the development of many chronic and degenerative disorders, including cardiovascular diseases, neurodegenerative conditions, cancer, and age-related illnesses. Beyond causing direct damage to macromolecules, disrupted REDOX signaling affects cellular homeostasis, alters inflammatory responses, and modifies metabolic control, leading to disease onset and progression. Therefore, targeting oxidative pathways offers a promising therapeutic approach for managing chronic diseases. Naturally derived antioxidants, especially phytochemicals such as polyphenols, flavonoids, and carotenoids, have been identified as novel REDOX modulators with diverse…

• AT
  Aimmune Therapeutics
• NR
  National Research Foundation
• DO
  Department of Science and Technology, Ministry of Science and Technology, India
• AU
  Amity University
• GU
  Gachon University

  Award: GCU-202206050001
• NR
  National Research Foundation of Korea

  Awards: RS-2020-NR049589, RS-2025-00555975