A regulatory network promotes apoplastic alkalinization to prime plant immunity in tissues distal to site of infection

-ATPases to dampen their activity, leading to alkalinization. The distal alkalinization is accompanied by the transcriptional activation of phytocytokines, including plant elicitor peptides, serine-rich endogenous peptides, and their receptors. We show that these phytocytokines promote distal alkalinization and disease resistance, whereas the apoplastic alkalinization sensitizes the phytocytokine perception that further induces phytocytokine genes. Our study suggests that apoplastic alkalinization and phytocytokine gene expression mutually potentiate and act as a combined signal that propagates in local-distal communication and disease resistance priming.

• GC
  Gatsby Charitable Foundation
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Awards: 310030_212382, 31003A_182625, 320030_228294
• NN
  National Natural Science Foundation of China

  Award: 32120103004
• UZ
  Universität Zürich
• ER
  European Research Council
• H2
  Horizon 2020
• KT
  Key Technologies Research and Development Program

  Award: 2021YFA1300701
• NK
  National Key Research and Development Program of China
• HE
  HORIZON EUROPE Reforming and enhancing the European Research and Innovation system

  Award: 773153