Breaking the outer membrane barrier: structure, targets, and antimicrobial strategies for Gram-negative bacteria

Multidrug resistance in Gram-negative bacteria has become a significant global public health challenge, threatening human health and clinical treatment outcomes. The unique outer membrane structure of these pathogens greatly limits antibiotic penetration, serving as the core mechanism of resistance. This paper systematically analyses antimicrobial strategies targeting the outer membrane of Gram-negative bacteria, mainly including: (1) directly disrupting the outer membrane structure and enhancing drug permeability; (2) inhibiting the biosynthesis or transport pathways of key outer membrane components; (3) using natural pathways to facilitate drug entry into the cell; (4) inhibiting efflux pumps to block efflux…

• NN
  National Natural Science Foundation of China

  Award: 82301026
• PG
  People's Government of Jilin Province
• ED
  Education Department of Jilin Province