articleAngewandte Chemie International EditionFeb 24, 2026HYBRID OA

Catalysis AI Agent Guides Discovering the Universal Design Principle of Cu‐Based Single‐Atom Alloy Catalysts for CO 2 Electroreduction

Beijing University of Chemical Technology · Tarim University · +3 more institutions

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Abstract

ABSTRACT Copper (Cu)‐based single‐atom alloys (SAAs) represent a promising strategy for optimizing the electroreduction of CO 2 (CO 2 R) to multi‐carbon products (C 2+ ). However, the diverse enhancement degrees of C 2+ selectivity brought about by various dopants have not yet been rationalized, which lead to the absence of guidelines for further designing desired Cu‐based SAAs. Herein, guided by the Catalysis AI Agent developed based on large‐scale data + large language model, as well as the Digital Catalysis Platform (the DigCat experimental database), we performed first‐principles calculations to evaluate C 2+ products selectivity trends through identifying the energy barrier of rate‐determining step (RDS)…

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