Electrospun PLA/PVP K90 Biphasic-Release Sublingual Film for Motion Sickness Treatment
University of Shanghai for Science and Technology · Macao Polytechnic University
Abstract
To overcome the limitations of traditional motion sickness medications—slow onset of action, short duration of efficacy, and poor patient compliance—this study employed coaxial electrospinning technology. Poly(lactic acid) (PLA) and polyvinylpyrrolidone K90 (PVP K90) were used as composite carrier materials. The sheath layer is composed of highly hydrophilic PVP K90, loaded with the antihistamine diphenhydramine (DPH). The core layer, composed of biodegradable PLA with excellent sustained-release properties, carries the anticholinergic drug scopolamine hydrobromide (SH). This core–sheath nanostructured nanofiber sublingual film delivers dual anti-motion sickness drugs. A series of characterization tests…
Citation impact
- FWCI
- 47.72
- Percentile
- 100%
- References
- 0
Authors
6- WZWenwen ZhangCorresponding
University of Shanghai for Science and Technology
- QWQilin Wang
University of Shanghai for Science and Technology
- WYWei Yi
University of Shanghai for Science and Technology
- HWHongxi Wang
University of Shanghai for Science and Technology
- DYDeng-Guang Yu
University of Shanghai for Science and Technology
Topics & keywords
- Motion sickness
- Diphenhydramine
- Anticholinergic
- Polyvinylpyrrolidone
- Drug delivery
- Tonicity
- Drug
- No poverty