Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

Ferroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and the accumulation of phospholipid peroxides that culminate in lethal membrane damage. Over the past decade, emerging evidence supports the concept that ferroptosis can be harnessed as an effective strategy to suppress tumor growth, particularly in therapy-resistant cancer cells undergoing epithelial-mesenchymal transition and in cancer stem cells. Given that ferroptosis is mechanistically and morphologically different from other known programmed cell death forms, increasing critical findings have shed light on mechanisms by which ferroptosis is regulated, and context-dependent cancer phenotype which is…

• NN
  National Natural Science Foundation of China

  Award: 31902326
• GO
  Government of Jiangsu Province
• MU
  Mendelova Univerzita v Brně
• PA
  Priority Academic Program Development of Jiangsu Higher Education Institutions