MnFe 2 O 4 Nanospheres with NIR-II-Responsive Photothermal, Photodynamic, and Enzyme-Mimicking Chemodynamic Activities for Cancer Therapy
Harbin University of Science and Technology · nLIGHT (United States) · +2 more institutions
Abstract
Near-infrared-II (NIR-II, 1000-1350 nm) phototherapy offers deep tissue penetration and precise tumor ablation, yet its efficacy is hindered by the heterogeneous tumor microenvironment (TME) (hypoxia, acidity, and elevated H2O2). Herein, MnFe2O4 nanospheres with TME-responsive and NIR-II-activatable properties were synthesized via a one-pot solvothermal method by varying the reaction time. Under 1064 nm irradiation, the optimized reaction time of 24 h nanoferrites (MFO-24) exhibited a photothermal conversion efficiency of 53.43% for PTT and generated singlet oxygen (1O2) with a quantum yield of 86.3% for PDT. In the TME, the MFO-24 catalyzed Fenton reactions (Fe2+/Fe3+, Mn2+/Mn4+) to produce hydroxyl radicals…
Citation impact
- FWCI
- 78.22
- Percentile
- 100%
- References
- 38
Authors
10- XLXuejiao LiCorresponding
Harbin University of Science and Technology, nLIGHT (United States), Harbin Engineering University, Catalytic Materials (United States)
- LLLige Liu
Harbin University of Science and Technology, Catalytic Materials (United States)
- RLRui Li
Harbin University of Science and Technology, Catalytic Materials (United States)
- NFNa Fan
Harbin University of Science and Technology, Catalytic Materials (United States)
- YMY. M. Wang
Harbin University of Science and Technology, Catalytic Materials (United States)
Topics & keywords
- Singlet oxygen
- Biocompatibility
- Radical
- Photothermal therapy
- Cancer therapy
- Reactive oxygen species
- Hyperthermia
- Cytotoxicity