Metabolic modulation of TCA cycle by S-nitrosylation in Monascus spp.
Guangxi Medical University · Huazhong Agricultural University · +1 more institution
Abstract
Monascus spp. produces several beneficial secondary metabolites (SMs), such as Monacolin K and Monascus pigments, which have wide applications in the pharmaceutical and food industries. Various factors, including gene expression, regulate the metabolic processes of Monascus spp. Furthermore, S -nitrosylation also modulates the activity of its metabolic enzymes. However, the specific regulatory role and mechanisms of S-nitrosylation in the metabolic pathways of Monascus spp. remain unexplored. In this study, quantitative S -nitrosoproteomics of M. purpureus identified 352 modified proteins, representing 12% of the total protein content in M. purpureus HJ11. S -nitrosylated proteins were predominantly…
Citation impact
- FWCI
- 145.29
- Percentile
- 100%
- References
- 49
Authors
4- ZMZitong Meng
Guangxi Medical University, Huazhong Agricultural University
- YTYingao Tan
Huazhong Agricultural University, Hubei University of Technology
- YDYali Duan
Huazhong Agricultural University, Hubei University of Technology
- MLMu LiCorresponding
Huazhong Agricultural University, Hubei University of Technology
Topics & keywords
- Monascus
- Monascus purpureus
- Citric acid cycle
- Enzyme
- Metabolic pathway
- Metabolite
Funding
- NNNational Natural Science Foundation of ChinaAward: 32572534
- CPChina Postdoctoral Science FoundationAwards: 2025MD774066, GZC20250505
- NUNational University's Basic Research Foundation of China
- FRFundamental Research Funds for the Central UniversitiesAward: 2662024SZ003
- YSYouth Science Foundation of Guangxi Medical UniversityAward: GXMUYSF202507