Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies

Fibrosis is a maladaptive pathophysiological process characterized by excessive deposition of extracellular matrix resulting from dysregulated tissue repair responses. Fibrosis can affect nearly all organ systems, such as the lung, heart, liver, and kidney. Persistent fibrotic remodeling leads to architectural distortion, loss of function, organ failure, and ultimately increased mortality. These devastating outcomes highlight the urgent need for effective antifibrotic therapies. Advances in multiomics technologies have revealed that fibrosis represents a dynamic alteration spanning the molecular, cellular, microenvironmental, and organ levels. Despite impressive progress in our understanding of fibrogenesis…

• NN
  National Natural Science Foundation of China

  Awards: 82370869, 82025007, U24A20676, 82170874
• CP
  China Postdoctoral Science Foundation
• SU
  Sichuan University
• WC
  West China Hospital, Sichuan University

  Award: 1.3.5