Gestational Oxygen-Timing Theory: Synthesis Papers on HIF-1α-Mediated Developmental Injury, Myelination, and Multi-System Outcomes

This collection comprises nine synthesis papers developing and extending the gestational oxygen-timing hypothesis — a framework proposing that disruptions to fetal oxygen supply during specific developmental windows produce latent, multi-system injury through HIF-1α-mediated mechanisms, with particular focus on oligodendrocyte precursor cell (OPC) maturation arrest and consequent myelination-dependent sensory and autonomic phenotypes. The papers span the following domains: Core mechanism: Gestational oxygen-timing alignment and the HIF-1α/OPC maturation arrest pathway as a unifying model for neurodevelopmental conditions including autism. Multi-organ programming: Multi-system gestational oxygen-timing model…