Advances in Pathogen Detection by Nanosensors: Biorecognition Strategies, Signal Amplification, and Platform Engineering
National Center for Nanoscience and Technology · University of Chinese Academy of Sciences · +2 more institutions
Abstract
The escalating global threat of infectious diseases, compounded by antimicrobial resistance (AMR), calls for improved diagnostic strategies. Conventional pathogen detection techniques─culture, enzyme-linked immunosorbent assay (ELISA), and microscopy─remain hindered by prolonged turnaround times, suboptimal sensitivity for low-abundance analytes, and operational intricacy. Nanosensor technologies have emerged as powerful enablers of rapid, ultrasensitive, and field-deployable diagnostics. This review delineates the convergence of three transformative domains: (1) advanced biorecognition strategies─including monoclonal antibodies, aptamers, bacteriophages, antimicrobial peptides, molecularly imprinted polymers,…
Citation impact
- FWCI
- 39.11
- Percentile
- 100%
- References
- 243
Authors
6- AZAroofa Zargul
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- HLHe Liu
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- WZWeiyu Zhang
National Clinical Research, Stomatology Hospital
- HWHui WangCorresponding
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- JLJing LiuCorresponding
National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
Topics & keywords
- Nanosensor
- Molecular diagnostics
- Microfluidics
- Biopharmaceutical
- CRISPR
- Loop-mediated isothermal amplification
- Diagnostic test
- Infectious disease (medical specialty)