articleCellMar 20, 2026HYBRID OA

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

NKNgee Kiat ChuaTJTania J. González-RoblesCJCameron J. ReddingtonJDJane Dudley-FraserRWRichard W. Birkinshaw

Walter and Eliza Hall Institute of Medical Research · New York University · +27 more institutions

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Abstract

To define and systematically characterize the human E3 ubiquitin ligase (E3) landscape, we generated the E3-ome, a compendium of E3s encoded by the human genome. The E3-ome integrates experimental data, bioinformatics, and published research, revealing 672 high-confidence E3s. We standardized E3 classifications to create a unified framework for annotation and comparative analysis. The E3-ome identified several previously unrecognized domains, motifs, E3 candidates, and relationships, expanding the diversity of E3s. Furthermore, the E3-ome mapped the spatial and physiological organization of E3s across human tissues and cell types, revealing context-dependent E3s. Genetic analyses identified disease-associated…

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Topics & keywords

Topics
Keywords
  • Compendium
  • Ubiquitin ligase
  • Ubiquitin-Protein Ligases
  • DNA ligase
  • DNA Ligases
  • DNA Transposable Elements
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