Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026

Sepsis, life-threatening acute organ dysfunction due to infection (1), is a global health priority (2,3) with approximately 49 million cases and 13 million sepsis-related deaths each year (4–6). Beyond being acutely deadly, sepsis contributes to new and worsened physical, cognitive, and mental health problems in many survivors (7,8). Early identification and treatment are critical to improving outcomes. The Surviving Sepsis Campaign (SSC) guidelines are intended to support clinicians caring for adult patients with sepsis, focusing on management in the hospital, the immediate prehospital setting, and the immediate post-hospital setting. These guidelines incorporate principles of antimicrobial stewardship…