Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications

Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and posttranscriptional or posttranslational modifications-plays a central role in malignant transformation and cancer progression. Cancer cells typically exhibit elevated basal ROS levels due to increased metabolic activity, mitochondrial dysfunction, and oncogene activation. This moderate oxidative stress promotes tumorigenesis by inducing DNA damage, genomic instability, and aberrant activation of…

• NR
  National Research Foundation
• IU
  Inje University
• NR
  National Research Foundation of Korea

  Awards: 2020R1A2C201215511, 2020R1A2C201215513