articleNew England Journal of MedicineJul 8, 2015BRONZE OA

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

Frederiksberg Hospital · Hvidovre Hospital · +17 more institutions

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Abstract

Background

Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is possible that a normal decline in FEV1 could also lead to COPD in persons whose maximally attained FEV1 is less than population norms.

Methods

We stratified participants in three independent cohorts (the Framingham Offspring Cohort, the Copenhagen City Heart Study, and the Lovelace Smokers Cohort) according to lung function (FEV1 ≥80% or

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